SRSF1 serves as a critical posttranscriptional regulator ...

SRSF1 plays a critical role in promoting the development of late thymocyte and maintaining peripheral T cell pool. On one hand, SRSF1 inhibits apoptosis of postselection thymocytes and upholds the mature thymocyte proliferation by modulating a series of genes, which are essential for T cell expansion and survival.FBXW7 mutations reduce binding of NOTCH1, leading to ...2019-2-21 · Novel mutations have been identified at lower frequencies 3 but can still point to central cellular pathways affected in the cancer cells. One of the genes affected by such mutations is F-box and WD40 repeat domain containing-7 (FBXW7).FBXW7 encodes an E3-ubiquitin ligase with 3 isoforms α, β, and γ that differ only in their N-termini due to alternative …

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Recruitment of IκBα to the hes1 promoter is associated ...

2004-11-23 · The NF-κB pathway plays a pivotal role in proliferation, differentiation, apoptosis, and immune responses in mammals. The NF-κB inhibitor, IκB, has classically been characterized for its ability to sequester NF-κB transcription factors in the cytoplasm. Nevertheless, a nuclear fraction of IκBα has consistently been detected and associated with repression of nuclear NF-κB vestigation of novel signals induced by ...Macrophages play key roles in innate immune responses. They phagocytose and destroy bacteria, and are activated by various microbial products, recognized through a variety of pattern recognition receptors, including toll-like receptors (TLRs). Engagement of TLRs triggers various intracellular signals, leading to the release of mediators that help orchestrate both the innate …

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Developing a persuasive Regulatory Business Plan (RBP ...

2019-1-4 · This is a challenging part of the project - the candidate''s RBP must demonstrate that there is a market for their products and services, and also be aware of the competition and their expected share in the market. The RBP must also demonstrate its understanding of the dynamics of the market and how the proposed bank will meet customer needs.Phospholipid oxidation generates potent …2015-3-13 · Caton ML, Smith-Raska MR, Reizis B (2007) Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. ... Palinski W, Hörkkö S, Miller E, Steinbrecher UP, Powell HC, Curtiss LK, Witztum JL (1996) Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice.

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Epstein-Barr Virus | SpringerLink

Epstein-Barr virus (EBV), like all human herpesviruses, infects almost all of the world''s population with an asymptomatic or trivial primary infection followed by lifelong persistence. Despite the ubiquitous nature of EBV and its potent in vitro immortalizing ability, the persistent infection is only rarely associated with disease.Expert Profile: aronowbj | Research Directory2021-11-21 · Ren J, Jegga AG, Zhang M, Deng J, Liu J, Gordon CB, Aronow BJ, Lu LJ, Zhang B, Ma J (2011. ) A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome.Hum Mol Genet,, …

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(PDF) Computational Study of Synthetic Agonist Ligands of ...

2013-3-25 · Tino Wolter, Thomas Steinbrecher, Marcus Elstner * Department of Theoretical Chemical Biology, Institute for Physical Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Ge rmany. Abstract nate immune signalling at the intestinal epithelium in ...RBP-J; recombination signal-binding protein for immunoglobulin kappa J region. ... Steinbrecher KA, Harmel-Laws E, Sitcheran R, Baldwin AS (2008) Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic …

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Steric and Allosteric Effects of Fatty Acids on the ...

Thomas Bernd Steinbrecher; ... AGP is the most important transporter for basic and neutral drugs, apoD, apoM, and RBP mainly bind endogenous molecules such as …Control of CNS Functions by RNA-Binding Proteins in ... · Purpose of Review This review summarizes recent studies on the molecular mechanisms of RNA-binding proteins (RBPs) that control …

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Genetically engineered mouse models for studying ...

Notch (RBP‐J, Pofut1) Notch receptors undergo proteolytic cleavage to release the Notch intracellular domain (NICD). These translocate into the nucleus to form a transcriptional activator complex with recombination signal binding protein for Igκ J region (RBP‐J) and intestinal epithelial cells; this complex activates Notch target genes.FBXW7 mutations reduce binding of NOTCH1, leading to ...2019-2-21 · Although the majority of mutations are shared by all 3 isoforms of FBXW7, 12% affect the FBXW7α-isoform only, of which 80% lead to the insertion/deletion (indel) resulting in amino acid p.(Gly16delinsValArg; here referred to as T15VR) (Figure 1A-B).To understand which FBXW7 isoform is most relevant for the pathogenesis of CLL, we quantified expression of the …

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Genetically Engineered Mouse Models for Studying ...

2021-10-28 · Notch (RBP-J, Pofut1) Notch receptors undergo proteolytic cleavage to release the Notch intracellular domain (NICD). These translocate into the nucleus to form a transcriptional activator complex with recombination signal binding protein for Igκ J region (RBP-J), and intestinal epithelial cells, this complex activates Notch target genes duction of CD36 by all‐trans retinoic acid: retinoic ...2001-3-20 · Vitamin A is required for several events in development and cell regulation ().Moreover, this lipid-soluble vitamin and its physiologically active derivatives, the retinoids all-trans retinoic acid (atRA) and 9-cis retinoic acid (9-cisRA), have been implicated in severaldiseases, including inflammatory disorders and cancer ().Vitamin A binds to the retinol …

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JCI

2011-11-7 · Anest V, Hanson JL, Cogswell PC, Steinbrecher KA, Strahl BD, Baldwin AS. A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature. 2003;423(6940):659–663.Publications - Ulm University2020-6-15 · Steinbrecher D, Jebaraj BMC, Schneider C, Edelmann J, Cymbalista F, Leblond V, Delmer A, Ibach S, Tausch E, Scheffold A, Bloehdorn J, Hallek M, Dreger P, Döhner H, Stilgen S. Telomere length in poor-risk chronic lymphocytic leukemia: associations with disease characteristics and outcome. Leuk Lymphoma. 2017 Oct 24:1.

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Genetically engineered mouse models for studying ...

2015-9-21 · Notch (RBP-J, Pofut1) Notch receptors undergo proteolytic cleavage to release the Notch intracellular domain (NICD). These translocate into the nucleus to form a transcriptional activator complex with recombination signal binding protein for Igκ J region (RBP-J) and intestinal epithelial cells; this complex activates Notch target genes.Cruciferous vegetable supplementation in a controlled diet ...2011-1-27 · Cruciferous vegetable intake is inversely associated with the risk of several cancers. Isothiocyanates (ITC) are hypothesized to be the major bioactive constituents contributing to these cancer-preventive effects. The polymorphic glutathione-S-transferase (GST) gene family encodes several enzymes which catalyze ITC degradation in vivo. We utilized high throughput …

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Inflammation-mediated Notch signaling skews Fanconi …

2013-9-1 · In vitro T cell differentiation assay. 4000 LSK cells isolated from Notch-eGFP-Fanca +/+ or Notch-eGFP-Fanca −/− were seeded to 24-well plate pre-coated with OP9-DL1 stromal cells (20,000 cells plated the day before the co-culture).The co-culture was conducted in α-MEM medium (Invitrogen, Grand Island, NY) supplemented with 20% fetal bovine serum and the …Conformational Equilibria and Free Energy Profiles for the ...For RBP, a pioneering umbrella sampling study by Ravindranathan et al. could identify a ligand induced shift in the equilibrium between an open and a …

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Structural mechanisms of selectivity and gating in anion ...

2018-8-29 · c, Retinal-binding pocket (RBP) of iC++ at pH 8.5 and 6.5; 2F o − F c maps (blue mesh, contoured at 1σ) and F o − F c maps (green and red meshes, contoured at 3σ and −3σ, respectively .. duction of CD36 by all‐trans retinoic acid: retinoic ...2001-3-20 · Vitamin A is required for several events in development and cell regulation ().Moreover, this lipid-soluble vitamin and its physiologically active derivatives, the retinoids all-trans retinoic acid (atRA) and 9-cis retinoic acid (9-cisRA), have been implicated in severaldiseases, including inflammatory disorders and cancer ().Vitamin A binds to the retinol …

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FBXW7 mutations reduce binding of NOTCH1, leading to ...

2019-2-21 · Novel mutations have been identified at lower frequencies 3 but can still point to central cellular pathways affected in the cancer cells. One of the genes affected by such mutations is F-box and WD40 repeat domain containing-7 (FBXW7).FBXW7 encodes an E3-ubiquitin ligase with 3 isoforms α, β, and γ that differ only in their N-termini due to alternative …SRSF1 serves as a critical posttranscriptional regulator ...SRSF1 plays a critical role in promoting the development of late thymocyte and maintaining peripheral T cell pool. On one hand, SRSF1 inhibits apoptosis of postselection thymocytes and upholds the mature thymocyte proliferation by modulating a series of genes, which are essential for T cell expansion and survival.

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Frontiers | The Dynamics of B Cell Aging in Health and ...

Aging is considered to be an important risk factor for several inflammatory diseases. B cells play a major role in chronic inflammatory diseases by antibody secretion, antigen presentation and T cell regulation. Different B cell subsets have been implicated in infections and multiple autoimmune diseases. Since aging decreases B cell numbers, affects B cell subsets and impairs antibody ...Metabolic Flux Analysis of Plastidic Isoprenoid ...Abstract. The plastidic 2-C-methyl-d-erythritol-4-phosphate pathway is one of the most important pathways in plants and produces a large variety of essential isoprenoids s regulation, however, is still not well understood. Using the stable isotope 13 C-labeling technique, we analyzed the carbon fluxes through the MEP pathway and into the major plastidic isoprenoid products in …

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Genetically Engineered Mouse Models for Studying ...

2021-10-28 · Notch (RBP-J, Pofut1) Notch receptors undergo proteolytic cleavage to release the Notch intracellular domain (NICD). These translocate into the nucleus to form a transcriptional activator complex with recombination signal binding protein for Igκ J region (RBP-J), and intestinal epithelial cells, this complex activates Notch target genes.Thermodynamics of Binding of 2-Methoxy-3 …2019-5-25 · In the present study we examine the thermodynamics of binding of two related pyrazine-derived ligands to the major urinary protein, MUP-I, using a combination of isothermal titration calorimetry (ITC), X-ray crystallography, and NMR backbone 15N and methyl side-chain 2H relaxation measurements. Global thermodynamics data derived from ITC indicate that …

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Innate immune signalling at the intestinal epithelium in ...

RBP-J; recombination signal-binding protein for immunoglobulin kappa J region. ... Steinbrecher KA, Harmel-Laws E, Sitcheran R, Baldwin AS (2008) Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic …Phospholipid oxidation generates potent …2015-3-13 · Caton ML, Smith-Raska MR, Reizis B (2007) Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. ... Palinski W, Hörkkö S, Miller E, Steinbrecher UP, Powell HC, Curtiss LK, Witztum JL (1996) Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice.

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Control of CNS Functions by RNA-Binding Proteins in ...

Purpose of Review. This review summarizes recent studies on the molecular mechanisms of RNA-binding proteins (RBPs) that control neurological functions and pathogenesis in various neurodevelopmental and neurodegenerative …Computational Study of Synthetic Agonist Ligands of ...2013-3-25 · For RBP, a pioneering umbrella sampling study by Ravindranathan et al. could identify a ligand induced shift in the equilibrium between an open and a closed form of the receptor . Similarly to the case here, for the ligand-free receptor an open structure dominates the conformational ensemble, which upon ligand binding shifts to strongly favor ...

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FBXW7 mutations reduce binding of NOTCH1, leading to ...

2019-2-21 · Novel mutations have been identified at lower frequencies 3 but can still point to central cellular pathways affected in the cancer cells. One of the genes affected by such mutations is F-box and WD40 repeat domain containing-7 (FBXW7).FBXW7 encodes an E3-ubiquitin ligase with 3 isoforms α, β, and γ that differ only in their N-termini due to alternative …JCI - Crosstalk between the canonical NF-κB and Notch ...2011-11-7 · Anest V, Hanson JL, Cogswell PC, Steinbrecher KA, Strahl BD, Baldwin AS. A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature. 2003;423(6940):659–663.

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Metabolic Flux Analysis of Plastidic Isoprenoid ...

Abstract. The plastidic 2-C-methyl-d-erythritol-4-phosphate pathway is one of the most important pathways in plants and produces a large variety of essential isoprenoids s regulation, however, is still not well understood. Using the stable isotope 13 C-labeling technique, we analyzed the carbon fluxes through the MEP pathway and into the major plastidic isoprenoid products in …Cruciferous vegetable supplementation in a controlled diet ...2011-1-27 · Cruciferous vegetable intake is inversely associated with the risk of several cancers. Isothiocyanates (ITC) are hypothesized to be the major bioactive constituents contributing to these cancer-preventive effects. The polymorphic glutathione-S-transferase (GST) gene family encodes several enzymes which catalyze ITC degradation in vivo. We utilized high throughput …

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(PDF) Ocular coloboma: A reassessment in the age of ...

180250 RBP deficie ncy I AD 10q24 RBP4 Seeliger et al. 65. 120330 Renal-coloboma I, R, O,M AD 10q24.3–25q.1 PAX2 Eccles and Schimmenti. 58. 120200 Ocular coloboma R, C, O AD 11p13 PAX6 Azuma et ...Isotretinoin and neuropsychiatric side effects: Continued ...2021-12-1 · Isotretinoin is an isomer of the active form of Vitamin A, retinoic acid, and both are highly teratogenic. A number of cases of neuropsychiatric side effects including depression, suicidality, violence, aggression, anxiety and psychosis have been associated with isotretinoin use with evidence for a causal rol.

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Docking and Ligand Binding Affinity: Uses and Pitfalls

2020-8-21 · In this review article, we will explore the foundations of different classes of docking and scoring functions, their possible limitations, and their suitable application domains. We also provide assessments of several scoring functions on weakly-interacting protein-ligand complexes, which will be useful information in computational fragment-based drug design or virtual screening.A nuclear role for Kaposi''s sarcoma-associated herpesvirus ...2008-5-12 · Kaposi''s sarcoma-associated herpesvirus (KSHV)-encoded viral FLICE inhibitory protein K13 interacts with a cytosolic IκB kinase (IKK) complex to activate nuclear factor-κB (NF-κB). We recently ...

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Phospholipid oxidation generates potent …

2015-3-13 · Caton ML, Smith-Raska MR, Reizis B (2007) Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. ... Palinski W, Hörkkö S, Miller E, Steinbrecher UP, Powell HC, Curtiss LK, Witztum JL (1996) Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice veloping a persuasive Regulatory Business Plan (RBP ...2019-1-4 · This is a challenging part of the project - the candidate''s RBP must demonstrate that there is a market for their products and services, and also be aware of the competition and their expected share in the market. The RBP must also demonstrate its understanding of the dynamics of the market and how the proposed bank will meet customer needs.

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Van der Waals Interactions Dominate Ligand−Protein ...

2005-7-26 · Identification of the retinol-binding protein (RBP) interaction site and functional state of RBPs for the membrane receptor. The FASEB Journal 2008, 22 (4), 1043-1054. DOI: 10.1096/fj.07-8939com. Gilles Bruylants, René Wintjens, Yvan …Genetically Engineered Mouse Models for Studying ...2021-10-28 · Notch (RBP-J, Pofut1) Notch receptors undergo proteolytic cleavage to release the Notch intracellular domain (NICD). These translocate into the nucleus to form a transcriptional activator complex with recombination signal binding protein for Igκ J region (RBP-J), and intestinal epithelial cells, this complex activates Notch target genes.

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A nuclear role for Kaposi''s sarcoma-associated herpesvirus ...

2008-5-12 · Kaposi''s sarcoma-associated herpesvirus (KSHV)-encoded viral FLICE inhibitory protein K13 interacts with a cytosolic IκB kinase (IKK) complex to activate nuclear factor-κB (NF-κB). We recently ...Cruciferous vegetable supplementation in a controlled diet ...2011-1-27 · Cruciferous vegetable intake is inversely associated with the risk of several cancers. Isothiocyanates (ITC) are hypothesized to be the major bioactive constituents contributing to these cancer-preventive effects. The polymorphic glutathione-S-transferase (GST) gene family encodes several enzymes which catalyze ITC degradation in vivo. We utilized high throughput …

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